Melanoma de Vulva. Reporte de un Caso

[Vulvar melanoma. Report of a case]

Juan Jose Jimenez Hiciano1, Jorge Lasso de la Vega Zavala2

1. Instituto Oncológico Nacional de Panamá, Panamá, Rep. de Panamá; 2. Dirección de Docencia, Instituto Oncológico Nacional, Panamá, Rep. Panamá.

Publicado: 2023-09-10

Descargas

Resumen

El cáncer de vulva representa solo el 1% de los canceres en las mujeres, siendo el melanoma maligno el menos frecuente dentro de este tipo de cáncer. Se presenta en mujeres de edad avanzada. Su manejo es principalmente quirúrgico y tiene una elevada mortalidad principalmente por enfermedad metastásica. Presentamos el caso de una mujer que llegó con una masa en los labios mayores y fue diagnosticada como melanoma maligno vulvar, tratada con cirugía y radioterapia de forma oportuna, pero que presenta metástasis pulmonar, quien recibe actualmente tratamiento para esto.


Abstract

Vulvar cancer represents only 1% of cancers in women, being malignant melanoma the least frequent within this type of cancer. It occurs in older women. Its management is mainly surgical and has a high mortality mainly due to metastatic disease. We present the case of a woman who arrived with a mass in the labia majora and was diagnosed as vulvar malignant melanoma, treated with surgery and radiotherapy in a timely manner, but who presents pulmonary metastasis, who is currently receiving treatment for this.

Citas

[1] Cummins D L, Cummins J M, Pantle H. Cutaneous Malignant Melanoma: A review. Mayo Clinic Proceedings 4, 2006, P 500-507. DOI: https://doi.org/10.4065/81.4.500

[2] Tasseron E, Van der Esch E, Hart A. A clinicopathological study of 30 melanomas of the vulva. Gynecol Oncol. 1992; 46:170-5. DOI: https://doi.org/10.1016/0090-8258(92)90250-M

[3] Irvin WP Jr, Legallo RL, Stoler MH, Rice LW, Taylor PT Jr, Andersen WA. Vulvar melanoma: a retrospective analysis and literature review. Gynecol Oncol. 2001 Dec;83(3):457-65. DOI: https://doi.org/10.1006/gyno.2001.6337

[4] Laliscia C, Gadducci A, Montrone S, Tana R, Morganti R, Fabrini MG. Radiotherapy as Definitive Treatment of Patients with Primary Vulvar Carcinoma Unfit for Surgery and with Recurrent Vulvar Carcinoma After Primary Radical Surgery: Results of a Retrospective Single-center Study. Anticancer Res. 2016 Jan;36(1):387-91.

[5] Wang D, Xu T, Zhu H, Dong J, Fu L. Primary malignant melanomas of the female lower genital tract: clinicopathological characteristics and management. Am J Cancer Res. 2020 Dec 1;10(12):4017–37.

[6] Egger EK, Stope MB, Recker F, Konsgen D, Landsberg J, Frohlich A, et al. Lower genital tract melanomas: staging, predictors of outcome, and new therapeutic options. Anticancer Res. 2021 Feb;41(2):999–1004. DOI: https://doi.org/10.21873/anticanres.14854

[7] Boer FL, Ten Eikelder MLG, Kapiteijn EH, Creutzberg CL, Galaal K, van Poelgeest MIE. Vulvar malignant melanoma: pathogenesis, clinical behaviour and management: review of the literature. Cancer Treat Rev. 2019; 73:91–103. DOI: https://doi.org/10.1016/j.ctrv.2018.12.005

[8] Irvin W, Legallo R, Stoler M, Rice L, Taylor P, Andersen W. Vulvar melanoma: A retrospective analysis and literature re- view. Gynecol Oncol. 2001; 83: 457-65. DOI: https://doi.org/10.1006/gyno.2001.6337

[9] Bradgate MG, Rolleson TP, McConkey CC. Malignant melano- ma of the vulva: a clinicopathological study of 50 women. Br J Obstet. Gynecol. 1990; 97: 124-33. DOI: https://doi.org/10.1111/j.1471-0528.1990.tb01737.x

[10] Blessing K, Kernohan NM, Miller ID. Malignant melanoma of the vulva: Clinicopathological features. Int J Gynecol Cancer. 1991;1:81-7. DOI: https://doi.org/10.1111/j.1525-1438.1991.tb00020.x

[11] Naik PP. Cutaneous Malignant Melanoma: A Review of Early Diagnosis and Management. World J Oncol. 2021 Feb;12(1):7-19. DOI: https://doi.org/10.14740/wjon1349

[12] Albert A, Lee A, Allbright R, Vijayakumar S. Vulvar melanoma: an analysis of prognostic factors and treatment patterns. J Gynecol Oncol. 2020 Sep;31(5):e66. DOI: https://doi.org/10.3802/jgo.2020.31.e66

[13] Boer FL, Ten Eikelder MLG, Kapiteijn EH, Creutzberg CL, Galaal K, van Poelgeest MIE. Vulvar malignant melanoma: pathogenesis, clinical behaviour and management: review of the literature. Cancer Treat Rev. 2019;73:91–103. DOI: https://doi.org/10.1016/j.ctrv.2018.12.005

×